New Research on a Popular Sleep Supplement Raises Scientists' Concerns

New Research on a Popular Sleep Supplement Raises Scientists' Concerns

A Popular Supplement Shows a Worrying Link to Heart Failure

An analysis of adults with insomnia showed that those prescribed melatonin for more than a year were at increased risk of heart disease.

Death and Heart Failure

According to Science Alert, the study's findings were presented this month at the American Heart Association's Scientific Sessions. Among more than 130,000 adults in multiple countries, those prescribed melatonin for an extended period had an 89% higher risk of developing heart failure over five years. They were also more likely to die from any cause compared to those who were not prescribed melatonin.

Those who took melatonin for more than a year were found to be 3.5 times more likely to be hospitalized for heart failure than those who did not take it. The risk of death from any cause also increased from 4.3% to 7.8% between the two groups. 

The research noted that these are preliminary findings and do not change current health recommendations, nor do they necessarily mean that melatonin—the fourth most popular natural product among adults in the United States—causes serious consequences.

Dietary Supplements

The study also emphasized that the results indicate that long-term use of melatonin requires further research to ensure its safety, especially since it is considered safe and well-tolerated for short-term use by non-pregnant or non-breastfeeding individuals, i.e., for about one to two months.

While research on the effects of this dietary supplement remains limited—a situation some researchers believe needs addressing, especially given its increasing popularity—medical researcher Ekinideleko Nadi of the New York State University Primary Care Center stated that melatonin supplements may not be as safe as commonly believed. He added that if the study's findings are confirmed, it could influence how doctors advise patients about sleep aids.

Over-the-Counter

Melatonin supplements mimic a hormone naturally produced by the brain to help maintain the body's circadian rhythm.

Sleep Disorders

Taking this supplement at the end of the day can also help some people sleep better. In the United States and many other countries, melatonin supplements are available without a prescription, meaning patients can take them without medical guidance or supervision regarding dosage or duration of use.